KARISMA is an innovative biostimulator based on type I collagen, obtained from silk threads, which naturally restores the skin's firmness and elasticity.

KARISMA is indicated for the medium-term correction of facial skin defects due to skin aging and / or loss of volume, therefore suitable for those who wish to reduce skin imperfections of the face, lips, redefine the contours or in the which there is a particularly unstructured subcutaneous tissue. It is also able to correct small scarring (eg acne scars).

Injectable, resorbable medical device, it is a bio-replenishing softfiller, as it naturally restores the pre-aging conditions, acting on the rejuvenation of the extracellular matrix.

KARISMA is:

• NATURAL – composed of totally natural substances and without the use of chemical binders,

• BIOLOGICAL – totally biocompatible, it promotes the innate regenerative capacity of the skin,

• SAFE – non allergenic, respectful of the natural origin of substances.

Synergy of formula:

• Rh Collagen - Combining collagen of the R-polypeptide chain α1 
  Increases the production of type I procollagen C-Peptide in fibroblasts. This type of peptides facilitate the wrapping of pro-collagen molecules in a triple helix conformation within the endoplasmic reticulum,

• CMC – Carboxymethylcellulose
  It has an anti-aging effect in the dermis: it inhibits the action of the hyaluronidase enzyme and preserves the endogenous hyaluronic acid, which, while remaining in the tissues, continues to perform its hydration and tissue repair activity in depth,

• HA – High molecular weight hyaluronic acid (1200-1500 kDa)
  It participates in the creation of a favorable environment for the proliferation and metabolism of fibroblasts.